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Nifedipine and anal fissure

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  • 24.04.2019
nifedipine and anal fissure
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Medical sphincterotomy has gained popularity as a treatment for anal fissure. Calcium channel blockers in topical forms could also be appropriate with low adverse effects. This was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. A prospective randomized controlled trial was conducted at two centers of Shahed University. One hundred and thirty patients with chronic anal fissure aged 18 to 60 years managed in our clinics were included in this study.
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The effect of topical nifedipine in treatment of chronic anal fissure.

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Anal Fissures: A Real Pain

Anal Fissures: A Real Pain. Patients with anal fissures frequently seek care for pain. Anal fissures also called fissure in ano are a common affliction— second only to hemorrhoids in terms of patient complaints about the anus. However, researchers have been unable to estimate the true incidence of anal fissures. Anal fissures occur only rarely in patients older than 65 years. Anal fissures start as acute tears: they can be superficial like a paper cut or so deep they split the dermis down to the underlying sphincter muscle.
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Is topical nifedipine effective for chronic anal fissures?

No laboratory tests are indicated at this time. A majority of anal fissures heal on their own, and no treatment is needed. If treatment is necessary, the goal is to relieve pain and constipation.
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Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing. For this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy. However, both of these methods may cause a degree of incontinence in some patients. The uptake of medical therapies that create a reversible chemical sphincterotomy has recently become widespread.
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