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PubMed Central. In Drosophila embryos the protein Naked cuticle Nkd limits the effects of the Wnt signal Wingless Wg during early segmentation. Using ectopic expression, we find that Nkd affects, in a cell-autonomous manner, a transduction step between the Wnt signaling components Dishevelled Dsh and Zeste-white 3 kinase Zw3. Zw3 is essential for repressing Wg target-gene transcription in the absence of a Wg signal, and the role of Wg is to relieve this inhibition.
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